Evolution of
Blood Cancer

Arbeitsgruppe Dr. med Judith S. Hecker

Research Interests

Research in our lab focuses on the age-related phenomenon and pre-malignant state clonal hematopoiesis of indeterminate potential (CHIP) as pro-inflammatory condition with particular interest in the impact of CHIP on human aging, novel immunotherapies such as CAR-T cells as well as hematologic and non-malignant disease development and maintenance. Further, our research group is interested in extracellular vesicles (EVs) in the mentioned disease states and their function as intercellular communication devices within the diseased bone marrow microenvironment, specifically in the context of novel immunotherapies. Further, we validate EV release inhibition as novel therapeutic strategy in several hematologic diseases. Methodologically, we are using latest standard technologies for the characterization of EVs and CHIP from human bone marrow cells and the analysis of their functional properties in in vitro culture, co-culture assays and preclinical mouse models. Our central aim is to forward the gained new functional insights to a direct clinical application and to translate novel therapies into early-phase clinical trials for cancer patients.

Principal Investigator
Dr. med. Judith Hecker
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Center for Translational Cancer Research (TranslaTUM)

Lab Members (alphabetical)

Kim Muñoz, PostDoc
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Christoph Nuernbergk, Clinican Scientist

Alexander Ochs, MD student

Lavinia Pachzelt, Clinician Scientist
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Anna Purcarea, Clinician Scientist
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Stefanie Stein, Technician
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Written applications including CV are welcome and should be forwarded by email to Dr. med. Judith S. Hecker.(link sends e-mail) 
We are currently looking for a highly motivated Postdoctoral Fellow.


Third party funding

BZKF (Leuchtturm Zelluläre Immuntherapien)
Fritz Thyssen Stiftung


Ihr Ansprechpartner


Dr. med.
Judith S. Hecker
Principal Investigator

Laboratory: TranslaTUM

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