Stem Cell
Physiology

Arbeitsgruppe Apl. Prof. Dr. Robert A.J. Oostendorp

Research Interests

Our research group studies the interactions of normal and malignant hematopoietic stem cells (HSCs) and their microenvironment, also called the niche. We are particularly interested in unraveling the underlying molecular mechanisms of these interactions and their feedback loops and how these affect the biological behavior of HSCs and leukemia-initiating cells (LICs).

Our research group studies the interactions of normal and malignant hematopoietic stem cells (HSCs) and their microenvironment, also called the niche. We are particularly interested in unraveling the underlying molecular mechanisms of these interactions and their feedback loops and how these affect the biological behavior of HSCs and leukemia-initiating cells (LICs).

Our main focus is the study of how functional changes in niche cells contribute to HSC maintenance and leukemogenesis in vivo. In our studies, we utilize a diverse toolbox of in-vitro and in-vivo genetic and other molecular models currently focused on the study of factors secreted by stromal cells of the microenvironment, such as the canonical Wnt-signaling inhibitors (SFRP1, SFRP2, and WNT5A) and stress-induced stromal factors such as CTGF. We are particularly interested how stromal cells signal to HSCs and LICs, and which intracellular processes are affected by these signals. For instance, we have found that stromal cells regulate actin assembly in HSCs and LICs. Actin assembly is important for diverse cellular functions, such as migratory responses, vesicle formation (endocytosis, exocytosis, autophagy), and cell division.

One of the main goals of these studies is to ascertain the relevance of the niche-regulated signaling pathways, and how these can be used as possible targets to improve HSC engraftment, as well as in the therapy of malignant myeloid disease.

Principal Investigator
Apl. Prof. Dr. Robert A.J. Oostendorp
E-Mail(link sends e-mail)

Laboratory: Trogerstrasse 32


Lab Members (alphabetical)

Nina Gauthier, Postgraduate Medical Student

Renate Hausinger, Postgraduate Medical Student

Franziska Hettler, Ph.D. Student

Sandra Romero-Marquez, Ph.D. Student

Dr. Christina Schreck, Postdoc

Theresa Sippenauer, Project Coordinator FOR2033, Ph.D. Student

Application

Written applications including CV are welcome and should be forwarded by e-mail(link sends e-mail) to Prof. Robert Oostendorp.

 

Third party funding

DFG – Single applications (OO 8)
DFG – Research Unit FOR2033
DFG – Research Center SFB1243(link is external)

 

Teaching Activities

Teaching (TUM Master of Science)
Lecture and Seminar series: Blood-forming stem cells as a model for somatic stem cells (TUM WZW Module Nr.: WZ2759 FA)
Research Internship: Hematopoietic stem cells (TUM WZW Module Nr.: WZ ME2677, also for LMU students) Scientific Project Planning (WPP)

 

Ihr Ansprechpartner

   

Apl. Prof. Dr. Robert A.J. Oostendorp
Principal Investigator

Laboratory: Trogerstr. 32

E-Mail(link sends e-mail)