Hematopoeitic Stem Cells and Microenvironment

Arbeitsgruppe Prof. Dr. med. Götze

Research Interests

We are focused on studying leukemic stem cells in acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS). In particular, we are interested in the interaction between leukemic stem cells and their microenvironment (niche) in the bone marrow to identify and target critical pathways directing clonal evolution and enabling survival of leukemic stem cells through interaction with the stem cell niche. Current projects have an emphasis on epigenetic changes in the bone marrow microenvironment during clonal evolution in MDS and AML and involve use of transgenic and transplantation mouse models as well as primary human bone marrow samples.

Our projects are funded by the German Research Foundation (DFG, SFB 1243), the Jose Carreras Leukämiestiftung (EPISTROMA) and the German Cancer Consortium (Deutsches Konsortium für Translationale Krebsforschung, DKTK).  We have close collaborations with researchers at the Department of Mathematics for computational modeling of stem cell hierarchies and with the Jose Carreras Research Institute in Barcelona for research projects on epigenetics, chromatin, metabolism and cell fate.

PhD candidates interested in translational cancer research, cancer biology, hematopoieis, leukemia and/or stem cells are encouraged to contact us. Prior experience with stem cell assays, flow cytometry, bioinformatics, genomics or computational biology is highly desirable.

Principal Investigator
Prof. Dr. med. Katharina Götze
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Laboratory: Trogerstrasse 32


Lab Members (alphabetical)

Jennifer Beauvarlet, Post-doc
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Dr. Judith Hecker, resident
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Michele Buck, PhD student
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Jonas Lang, medical student
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Romina Ludwig, PhD student

Luisa Vogel, medical student

Mark Van der Garde
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Application

Written applications including CV are welcome and should be forwarded by e-mail(link sends e-mail) to Prof. Katharina Götze.

 

Third party funding

DFG – Research Center SFB1243(link is external)
DJCLS Jose Carreras Leukämie Stiftung 14R/2018 2019-2021
DKTK Joint Funding CHOICE 2019-2021

 

Ihr Ansprechpartner

   

Prof. Dr. med. Katharina Götze Principal Investigator

Laboratory: Trogerstr. 32

E-Mail(link sends e-mail)