Hematopoeitic Stem Cells and Microenvironment

Arbeitsgruppe Prof. Dr. med. Götze

Research Interests

We are focused on studying hematopoietic stem cells in clonal hematopoiesis of indeterminate potential (CHIP) as well as in myeloid disorders such as myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML). In particular, we are interested in the interaction between mutated stem calls and their microenvironment (niche) in the bone marrow to identify and target critical pathways directing clonal evolution and enabling survival of leukemic stem calls through interaction with the stem cell niche, including characterization of extracellular vesicles. Current projects are focused on gaining a better understanding of which niche factors contribute to evolution from clonal hematopoiesis to myeloid disease as well as to relapse after allogeneic stemm cell transplantation with the ultimate goal of identifying niche dependencies that can be exploited for disease intervention.

Our projects are funded by the German Research Foundation (DFG), the Jose Carreras Leukämiestiftung, the German Cancer Consortium (Deusches Konsortium für Translationale Krebsforschung, DKTK) and the EU Horizon 2020 program. We have close collaborations with researchers at the Department of Mathematics for computational modeling of stem cell hierarchies and with the Jose Carreras Research Institute in Barcelona for research projects on epigenetics, chromatin, metabolism and cell fate and the Georg Speyer Haus in Frankfurt (Hind Medyouf) for in vivo and organoid niche models of myeloid diesease development.

PhD candidates interested in translational cancer research, cancer biology, hematopoieis, leukemia and/or stem cells are encouraged to contact us. Prior experience with stem cell assays, flow cytometry, bioinformatics, genomics or computational biology is highly desirable.

Application

Written applications including CV are welcome and should be forwarded by e-mail(link sends e-mail) to Prof. Katharina Götze.

 

Third party funding

Deutsche Jose Carreras Leukämiestiftung
DFG (FOR 2033, SFB 1243)
DKTK Joint Funding (CHOICE)
European Union Horizon 2020 innovative Training Network: INTERCEPT-MDS

 

Ihr Ansprechpartner

   

Prof. Dr. med. Katharina Götze Principal Investigator

Laboratory: Trogerstr. 32

E-Mail(link sends e-mail)