Molecular Oncology
and Cell Death

Horak P, Heining C, Kreutzfeldt S. Hutter B, Mock A, Hullein J, Frohlich M, Uhrig S, Jahn A, Rump A, Gieldon L, Mohrmann L, Hanf D, Teleanu V, Heilig CE, Lipka DB, Allgauer M, Ruhnke L, Lassmann A, Endris V, Neumann O, Penzel R, Beck K, Richter D, Winter U, Wolf S, Pfutze K, Georg C, Meissburger B, Buchhalter I, Augustin M, Aulitzky WE, Hohenberger P, Kroiss M, Schrimacher P, Schlenk RF, Keilholz U, Klauschen F, Folprecht G, Bauer S, Siveke JT, Brandts CH, Kindler T, Boerries M, Illert AL, von Bubnoff N, Jost PJ, Spiekermann K, Bitzer M, Schulze-Osthoff K, von Kalle C, Klink B, Brors B, Stenzinger A, Schrock E, Hubschmann D, Weichert W, Glimm H, Frohling S., Comprehensive Genomic and Transcriptomic Analysis for Guiding Therapeutic Decisions with Patients with rare cancers. Cancer Discov. 2021 PMID: 34112699

Wang X, Ros U, Agrawal D, Keller EC, Slotta-Huspenina J, Dill V, Shen B, Shi R, Herold T, Belka C, Misra R, Bassermann F, Garcia-Saez AJ, Jost PJ. MLKL promotes cellular differentiation in myeloid leukemia by facilitating the relase of G-CSF. Cell Death Differ. 2021 Jun 2. PMID: 34079078

Jayavelu AK, Schnöder TM, Perner F. Herzog C, Meiler A, Krrishnamoorthy G, Huber N, Mohr J, Edelmann-Stephan B, Austin R, Brandt S, Palandri F, Schröder N, Isermann B, Edlich F, Sinha AU, Ungelenk M, Hübner CA, Zeiser R, Rahmig S, Waskow C. Coldham I, Ernst T, Hochhaus A, Jilg S, Jost PJ, Mullally A, Bullingewr L, Mertens PR, Lane SW, Mann M, Heidel FH. Splicing factor YBX1 mediates persistence of JAK2-mutated neoplasms. Nature. 2020, 588(7836):157-163. PMID:33239784

Munkhbaatar E, Dietzen M, Agrawal D, Anton D, Jesinghaus M, Boxberg M, Pfarr N, Bidola P, Uhrig S, Höckendorf U, Meinhardt AL, Wahida A, Heid I, Braren R, Mishra R, Warth A, Muley T, Poh PSP, Wang X, Fröhling S, Steiger K, Slotta-Huspenina J, van Griensven M, Pfeiffer F, Lange S, Rad R, Spella M. Stathopoulos GT, Ruland J, Bassermann F, Weichert W, Strasser A, Branca C, Heikenwalder M, Swanton C, McGranahan N, Jost PJ. MCL-1 gains occur with high frequency in lung adenocarcinoma and can be targeted therapeutically. Nat Commun. 2020 11(1):4527. PMID: 32913197

Jost PJ, Vucic D. Regulation of Cell Death and Immunity by XIAP. Cold Spring Harb Perspect Biol. 2020. PMID: 31843992

Müller N, Fischer JC, Yabal M, Haas T, Poeck H, Jost PJ.
XIAP deficiency in hematopoietic recipient cells drives donor T-cell activation and GvHD in mice.
Eur J Immunol, 2018.

Jost PJ, Höckendorf U.
Necroinflammation emerges as a key regulator of hematopoiesis in health and disease.
Cell Death and Differentiation, 2018.

Lawlor KE*, Feltham R*, Yabal M*, Conos SA, Chen KW, Ziehe S, Grass C, Zhan Y, Nguyen T, Hall C, Vince AJ, Chatfield SM, D'Silva DB, Pang KC, Schroder K, Silke J, Vaux DL, Jost PJ*, Vince JE*.
XIAP Loss Triggers RIPK3- and Caspase-8-Driven IL-1beta Activation and Cell Death as a Consequence of TLR-MyD88-Induced cIAP1-TRAF2 Degradation.
Cell Rep, 2017.

Höckendorf U*, Yabal M*, Herold T, Munkhbaatar E, Rott S, Jilg S, Kauschinger J, Magnani G, Reisinger F, Heuser M, Kreipe H, Sotlar K, Engleitner T, Rad R, Weichert W, Peschel C, Ruland J, Heikenwalder H, Spiekermann K, Slotta-Huspenina J, Groß O and Jost PJ.
RIPK3 restricts myeloid leukemogenesis by promoting cell death and differentiation of leukemia initiating cells.
Cancer Cell, 2016.

Spinner S, Crispatzu G, Yi JH, Munkhbaatar E, Mayer P, Höckendorf U, Müller N, Li Z, Schader T, Bendz H, Hartmann S, Yabal M, Pechloff K, Heikenwalder M, Kelly GL, Strasser A, Peschel C, Hansmann ML, Ruland J, Keller U, Newrzela S, Herling M, Jost PJ.
Re-activation of mitochondrial apoptosis inhibits T-cell lymphoma survival and treatment resistance.
Leukemia, 2016.

Jilg S, Reidel V, Müller-Thomas C, König J, Schauwecker J, Höckendorf U, Huberle C, Gorka O, Schmidt B, Burgkart R, Ruland J, Kolb HJ, Peschel C, Oostendorp RA, Götze KS, Jost PJ.
Blockade of BCL-2 proteins efficiently induces apoptosis in progenitor cells of high-risk myelodysplastic syndromes patients.
Leukemia, 2016.

Yabal M, Müller N, Adler H, Knies N, Groß CJ, Damgaard RB, Kanegane H, Ringelhan M, Kaufmann T, Heikenwälder M, Strasser A, Groß O, Ruland J, Peschel C, Gyrd-Hansen M, Jost PJ.
XIAP Restricts TNF- and RIP3-Dependent Cell Death and Inflammasome Activation.
Cell Rep, 2014.

Damgaard RB*, Nachbur U*, Yabal M*, Wong WWL, Fiil BK, Kastirr M, Rieser E, Rickard JA, Bankovacki A, Peschel C, Ruland J, Bekker-Jensen S, Mailand N, Kaufmann T, Strasser A, Walczak H, Silke J, Jost PJ*#, Gyrd-Hansen M*#.
The ubiquitin ligase XIAP recruits LUBAC for NOD2 signaling in inflammation and innate immunity.
Molecular Cell, 2012.

Kaufmann, T., Strasser, A., Jost PJ.
Fas Death Receptor Signalling: Roles of Bid and XIAP.
Cell Death and Differentiation, 2012.

Vikstrom I., Carotta S., Lüthje K., Peperzak V., Jost PJ., Glaser S., Busslinger M., Bouillet P., Strasser A., Nutt SL., Tarlinton DM., Mcl-1 is Essential for Germinal Center Formation and B cell Memory,
Science, 2010.

Jost, PJ., Grabow, S., Gray, D., McKenzie, MD., Nachbur, U., Huang, DCS., Bouillet, P., Thomas, HE., Borner, C., Silke, J., Strasser, A., Kaufmann, T. XIAP discriminates between type I and type II FAS-induced apoptosis.
Nature, 2009.

(*: equal contribution; #: corresponding author)