molecular mechanisms
in cancer

Arbeitsgruppe Dr. Fernandez-Saiz

Research Interests

Ubiquitin is a small protein covalently linked to amino-acid residues of other polypeptides regulating protein homeostasis, localization and activation. Our lab focuses on the disclosure of the ubiquitinome controled by ubiquitin ligases and deubiquitinases (DUBs) with an emphasis on ubiquitylated proteins at the plasma membrane. We aim at studying ubiquitin molecular mechanisms that are deregulated in human diseases and often lead to tumor development, progression and clinical relapse. To adress these questions we integrate cutting edge protein biochemistry with preclinical models and patient samples in close collaboration with clinicians involved in the treatment of hematologic and lung malignancies. Our ultimate goal is to uncover new diagnostic biomarkers and innovative therapies for cancer treatment.

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Postdoc positions
If you are interested in doing a Postdoc in our lab, please contact Vanesa directly to discuss opportunities.

PhD, MD and M.Sc. student positions
We are looking for highly motivated students. Please contact Vanesa for inquiries for open PhD or MD student positions in the lab, as well as lab rotations for M.Sc. students.

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Vanesa Fernández, PhD
Principal Investigator

Laboratory: TranslaTUM

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